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Anotrit (Brand name: Cardizem) Online

  • €0,37
  • Brand name: Cardizem
  • Verfügbarkeit: Lagernd
  • Wirkstoff: Diltiazem
Anotrit wird zur Behandlung von Supraventrikulärer Tachykardie (eine Herzrhythmusstörung) verwendet.
Analog zu Anotrit (Brand name: Cardizem): Diltiazem  
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180 mg
Produktname Pro Pille Pro Packung  
30 pillen €1,98 €59,42
60 pillen €1,27 €118,85 €76,06
90 pillen €1,03 €178,27 €92,70
120 pillen €0,91 €237,70 €109,34
180 pillen €0,79 €356,55 €142,62
270 pillen €0,71 €534,82 €192,54
360 pillen €0,67 €713,10 €242,46
120 mg
Produktname Pro Pille Pro Packung  
30 pillen €1,24 €37,31
60 pillen €0,94 €74,61 €56,30
90 pillen €0,84 €111,92 €75,29
120 pillen €0,79 €149,23 €94,28
180 pillen €0,73 €223,84 €132,27
270 pillen €0,70 €335,76 €189,24
360 pillen €0,68 €447,68 €246,24
60 mg
Produktname Pro Pille Pro Packung  
60 pillen €0,66 €39,38
90 pillen €0,54 €59,06 €48,67
120 pillen €0,48 €78,75 €57,96
180 pillen €0,43 €118,13 €76,55
270 pillen €0,39 €177,19 €104,42
360 pillen €0,37 €236,25 €132,30

INDICATIONS

Anotrit is used for treating supraventricular tachycardia, a rhythm disturbance of the heart. It is also used for controlling heart rate response to other rhythm disturbances, specifically, atrial fibrillation and flutter. Anotrit is a calcium channel blocker. It works by slowing the electrical conduction in the heart, slowing heart rate, and/or normalizing heart rhythm.

INSTRUCTIONS 

Use Anotrit as directed by your doctor.

  • Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.
  • Your doctor may occasionally change your dose to make sure you get the best results from this medication.
  • Take Anotrit with a full glass of water. Swallow the pill whole. It is specially made to release medicine slowly in the body. Breaking or opening the pill would cause too much of the drug to be released at one time.
  • It is important to use Anotrit regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.
  • Do not stop taking this medication without first talking to your doctor. If you stop taking Anotrit suddenly, your condition may become worse.
  • If you are being treated for high blood pressure, keep using this medication even if you feel fine. 
  • If you miss a dose of Anotrit, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Anotrit.

STORAGE

Store Anotrit at room temperature away from moisture and heat. Keep Anotrit out of the reach of children and away from pets.

MORE INFO:

Active Ingredient: Diltiazem.

SAFETY INFORMATION

Do NOT use Anotrit if:

  • you are allergic to any ingredient in Anotrit
  • you have sick sinus syndrome or have second- or third-degree heart block and do not have a pacemaker, or very low blood pressure
  • you have atrial fibrillation or flutter and a pre-excitation syndrome (extra conduction pathway in the heart), such as Wolff-Parkinson-White syndrome (WPW) or Lown-Ganong-Levine syndrome (LGL)
  • you are receiving injectable beta-blockers (eg, metoprolol) or erythromycin.

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Anotrit. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have heart failure or have had a recent heart attack with lung congestion, heart block, low blood pressure, a very slow heart rate, or abnormal heart rhythm
  • if you have kidney or liver disease.

Some medicines may interact with Anotrit. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Cimetidine or protease inhibitors (eg, indinavir) because they may increase the actions and side effects of Anotrit
  • Rifampin because it may decrease the effectiveness of Anotrit
  • Amiodarone, cisapride, digoxin, erythromycin, protease inhibitors (eg, indinavir), quinidine, tricyclic antidepressants (eg, desipramine), theophylline, or general anesthetics because toxic effects on the heart may occur
  • Benzodiazepines (eg, midazolam), beta-blockers (eg, metoprolol), buspirone, carbamazepine, cilostazol, corticosteroids (eg, prednisone), cyclosporine, HMG-CoA reductase inhibitors (eg, atorvastatin), macrolide immunomodulators (eg, tacrolimus) because the risk of their side effects, some potentially life-threatening, may be increased by Anotrit.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Anotrit may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

  • Anotrit may cause dizziness. These effects may be worse if you take it with alcohol or certain medicines. Use Anotrit with caution. Do not drive or perform other possible unsafe tasks until you know how you react to it.
  • Anotrit may cause dizziness, lightheadedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.
  • Anotrit may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Anotrit. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.
  • Tell your doctor or dentist that you take Anotrit before you receive any medical or dental care, emergency care, or surgery.
  • Lab tests, including electrocardiogram (ECG), heart rate, and blood pressure monitoring, may be performed while you use Anotrit. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Use Anotrit with caution in the elderly; they may be more sensitive to its effects.
  • Anotrit should not be used in children; safety and effectiveness in children have not been confirmed.
  • Pregnancy and breast-feeding: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Anotrit while you are pregnant. Anotrit is found in breast milk. Do not breastfeed while taking Anotrit.

SIDE EFFECTS

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Constipation; dizziness; facial flushing; headache; weakness.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); hallucinations; irregular heartbeat; swelling of the feet or hands; symptoms of liver problems (eg, yellowing of the skin or eyes, dark urine, pale stools); tender, bleeding, or swollen gums.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

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Es ist wichtig, den Sicherheitsempfehlungen zu folgen und die Gegenanzeigen, Warnhinweise und Vorsichtsmaßnahmen zu berücksichtigen, damit sich das Risiko schlimmer Reaktionen und Nebenwirkungen reduziert. Es kommt leider bei Patienten mit Überempfindlichkeit gegen einigen Komponenten des Arzneimittels zu leichten bis schweren nachteiligen Reaktionen, die im Text unten zu finden sind. Um das Risiko ernster Folgen auszuschalten, wenden Sie sich an Ihren Therapeuten oder an einen Online-Facharzt. Man benötigt dringende medizinische Hilfe, wenn folgende Nebenwirkungen zu bemerken sind:

More Common

  • Body aches or pain
  • congestion
  • cough
  • dryness or soreness of the throat
  • fever
  • hoarseness
  • runny nose
  • tender or swollen glands in the neck
  • trouble swallowing
  • voice changes
  • Sneezing
  • stuffy nose

Less Common

  • Chest pain or discomfort
  • chills
  • diarrhea
  • difficult or labored breathing
  • feeling faint, dizzy, or lightheaded
  • feeling of warmth or heat
  • flushing or redness of the skin, especially on the face and neck
  • general feeling of discomfort or illness
  • headache
  • joint pain
  • loss of appetite
  • muscle aches and pains
  • nausea
  • shivering
  • slow or irregular heartbeat
  • sweating
  • swelling of the hands, ankles, feet, or lower legs
  • tightness in the chest
  • trouble sleeping
  • unusual tiredness or weakness
  • vomiting
  • Acid or sour stomach
  • belching
  • constipation
  • continuing ringing or buzzing or other unexplained noise in the ears
  • degenerative disease of the joint
  • difficulty with moving
  • hearing loss
  • heartburn
  • indigestion
  • lack or loss of strength
  • muscle aching or cramping
  • muscle pains or stiffness
  • pain or tenderness around the eyes and cheekbones
  • rash
  • stomach discomfort, upset, or pain
  • swollen joints

Incidence Not Known

  • Blistering, peeling, or loosening of the skin
  • itching
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • no heartbeat
  • red skin lesions, often with a purple center
  • red, irritated eyes
  • sores, ulcers, or white spots in the mouth or on the lips
  • Hair loss or thinning of the hair
Type Small Molecule
Accession Number DB00343  (APRD00473)
Groups Approved, Investigational
Synonyms
  • (+)-cis-5-[2-(dimethylamino)ethyl]-2,3-dihydro-3-hydroxy-2-(p-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one acetate ester
  • (2S-cis)-3-(acetyloxy)-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one
  • (2S,3S)-5-(2-(dimethylamino)ethyl)-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]thiazepin-3-yl acetate
  • Acetic acid (2S,3S)-5-(2-dimethylamino-ethyl)-2-(4-methoxy-phenyl)-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepin-3-yl ester
  • D-cis-diltiazem
  • Diltiazem
  • Diltiazemum
UNII EE92BBP03H
CAS number 42399-41-7
Weight Average: 414.518
Monoisotopic: 414.16132802
Chemical Formula C22H26N2O4S
InChI
InChI=1S/C22H26N2O4S/c1-15(25)28-20-21(16-9-11-17(27-4)12-10-16)29-19-8-6-5-7-18(19)24(22(20)26)14-13-23(2)3/h5-12,20-21H,13-14H2,1-4H3/t20-,21+/m1/s1
IUPAC Name
(2S,3S)-5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl acetate
Protein binding

70%-80%

Toxicity

LD50=740mg/kg (orally in mice)

Half life

3.0 - 4.5 hours

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