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Alacir (Brand name: Malegra DXT) Online

  • €1,01
  • Brand name: Malegra DXT
  • Verfügbarkeit: Lagernd
  • Wirkstoff: sildenafil
Analog zu Alacir (Brand name: Malegra DXT): Malegra DXT Plus  
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Addamo   Aggra   Akabar   Aladin   Alclimax   Almaximo   Alsigra   Altus   Amfidor   Assurans   Avixar   Activil   Adagrin   Adegra   Adonix   Afilon   Alfin   Andros   Androz   Apo-Sildenafil   Avigra   Azulsix   Alacir   Ambidext   Ariclaim   Ao Si Ping   APO-Duloxetine   Alacir  
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130 mg
Produktname Pro Pille Pro Packung  
20 pillen €1,84 €36,88
30 pillen €1,55 €55,32 €46,36
60 pillen €1,25 €110,64 €74,80
90 pillen €1,15 €165,97 €103,23
120 pillen €1,10 €221,29 €131,67
180 pillen €1,05 €331,93 €188,54
270 pillen €1,01 €497,90 €273,84

INDICATIONS

Alacir is a combination drug that is made of 2 active compounds, namely Sildenafil citrate and Duloxetine.

Sildenafil citrate gets dissolved in the blood, removes the blockage caused in the arteries and the blood vessels and increases the flow of blood to male organ thus providing men suffering from erectile dysfunction with hard and strong erections.

Duloxetine in Alacir works as an antidepressant which is shown to have a substantial effect on premature ejaculation ensuring long lasting sexual activity.

INSTRUCTIONS 

Take Alacir as directed by your doctor.

  • Take Alacir after a light meal.
  • Take Alacir by mouth with a full glass of water about 50 to 60 minutes before sexual activity. This allows the medication to get proper dissolved into the blood stream for better result.
  • Do not take Alacir more often than once daily.
  • If you miss a dose of Alacir and you still intend to engage in sexual activity, take it as soon as you remember. Continue to take it as directed by your doctor.

DOSAGE

Take the medicine as directed by your doctor.

The most prescribed dose of Alacir is 100mg of Sildenafil and 30mg of Duloxetine for most patients.

If you miss a dose of Alacir, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

STORAGE

Store Alacir between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Keep it out of the reach of children and away from pets.

MORE INFO:

Active Ingredients: Sildenafil Duloxetine

The effect of this medication lasts up to 4 hours.

Alacir should not be consumed on an everyday basis as it can get habitual within the person. Thus, this kind of consumption could lead to addiction of this medication in the person and bring out adverse side effects over the person.

In case of an overdose, immediately contact nearby poison control center or emergency room.

SAFETY INFORMATION

Do not take Alacir if:

  • you are allergic to any ingredient in Alacir
  • you are under mental stress or performing any physical activity
  • you have been advised by your doctor to avoid sexual activity because of heart problems
  • you are taking nitrates (eg, isosorbide, nitroglycerin) in any form (eg, tablet, capsule, patch, ointment), or nitroprusside
  • you use certain recreational drugs called 'poppers' (eg, amyl nitrate or nitrite, butyl nitrate or nitrite)

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Alacir. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have a deformed penis (eg, Peyronie disease), blood cell problems (eg, leukemia, sickle cell anemia)
  • if you have a history of high or low blood pressure, ulcers, bleeding problems, heart problems (heart failure, irregular heartbeat), or blood vessel problems
  • if you have a history of heart attack, stroke, or life-threatening irregular heartbeat, especially within the past 6 months.

Some medicines may interact with Alacir. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Alpha-blockers (eg, doxazosin), medicines for high blood pressure, nitrates (eg, isosorbide, nitroglycerin), or nitroprusside because severe low blood pressure with dizziness, lightheadedness, and fainting may occur
  • Azole antifungals (eg, itraconazole, ketoconazole), H2 antagonists (eg, cimetidine), HIV protease inhibitors (eg, ritonavir, saquinavir), macrolide antibiotics (eg, erythromycin), narcotic analgesics (eg, dihydrocodeine), or telithromycin because they may increase the risk of Alacir's side effects
  • Bosentan or rifampin because they may decrease Alacir's effectiveness.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Alacir interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

  • Alacir may cause dizziness, drowsiness, fainting, or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use Alacir with caution. Do not drive or perform other possible unsafe tasks until you know how you react to it.
  • Alacir may cause dizziness, lightheadedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.
  • Patients with heart problems who take Alacir may be at increased risk for heart-related side effects, including heart attack or stroke. Symptoms of a heart attack may include chest, shoulder, neck, or jaw pain; numbness of an arm or leg; severe dizziness, headache, nausea, stomach pain, or vomiting; fainting; or vision changes. Symptoms of a stroke may include confusion, vision or speech changes, one-sided weakness, or fainting. Contact your doctor or seek medical attention right away if you experience these symptoms.
  • Alacir does not stop the spread of HIV or other sexually transmitted diseases (STDs) to others through sexual contact. Use barrier methods of birth control (eg, condoms) if you have HIV infection or an STD.
  • Alacir will not prevent pregnancy. If your partner may become pregnant and you wish to avoid pregnancy, be sure to use an effective form of birth control.
  • Alacir may uncommonly cause mild, temporary vision changes (eg, blurred vision, sensitivity to light, blue/green color tint to vision). Contact your doctor if vision changes persist or are severe.
  • Do not use other medicines or treatments for ED while you are taking Alacir without first checking with your doctor.
  • Use Alacir with caution in the elderly; they may be more sensitive to its effects.
  • Alacir is not recommended for use in patients younger 18 years.

SIDE EFFECTS

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Headache, flushing, blurring of vision, runny nose, nausea and vomiting, indigestion, back or muscle pain.

The side effects given above may not cover all possible side effects. Patients who take Alacir may or may not experience the above listed symptoms as it depends upon the reaction of the body to the medicine. If the side effects worsen during the treatment by Alacir, contact the doctor or medical emergency unit as early as possible.

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Es ist wichtig, den Sicherheitsempfehlungen zu folgen und die Gegenanzeigen, Warnhinweise und Vorsichtsmaßnahmen zu berücksichtigen, damit sich das Risiko schlimmer Reaktionen und Nebenwirkungen reduziert. Es kommt leider bei Patienten mit Überempfindlichkeit gegen einigen Komponenten des Arzneimittels zu leichten bis schweren nachteiligen Reaktionen, die im Text unten zu finden sind. Um das Risiko ernster Folgen auszuschalten, wenden Sie sich an Ihren Therapeuten oder an einen Online-Facharzt. Man benötigt dringende medizinische Hilfe, wenn folgende Nebenwirkungen zu bemerken sind:

More Common

  • Body aches or pain
  • cough
  • difficulty having a bowel movement (stool)
  • dry mouth
  • ear congestion
  • frequent urination
  • headache
  • lack or loss of strength
  • loss of appetite
  • loss of voice
  • muscle aches
  • nausea
  • sleepiness or unusual drowsiness
  • sneezing
  • sore throat
  • stuffy or runny nose
  • sweating increased
  • trouble sleeping
  • weight loss

Less Common

  • Abnormal orgasm
  • acid or sour stomach
  • belching
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • change in taste
  • change or problem with discharge of semen
  • decreased interest in sexual intercourse
  • difficulty with moving
  • feeling of warmth or redness of the face, neck, arms, and occasionally, upper chest
  • heartburn
  • inability to have or keep an erection
  • indigestion
  • joint pain
  • longer than usual time to ejaculation of semen
  • loose stools
  • loss in sexual ability, desire, drive, or performance
  • loss of taste
  • muscle aching or cramping
  • muscle pains or stiffness
  • shakiness in the legs, arms, hands, or feet
  • stomach discomfort or upset
  • sudden sweating
  • swollen joints
  • trembling or shaking of the hands or feet

Incidence Not Known

  • Abdominal or stomach pain
  • area rash
  • blindness
  • blistering, peeling, or loosening of the skin
  • blurred vision
  • change in consciousness
  • chills
  • clay-colored stools
  • cold sweats
  • confusion
  • convulsions
  • dark urine
  • decreased urine output
  • decreased vision
  • difficulty swallowing
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • eye pain
  • fainting
  • fast or irregular heartbeat
  • general tiredness or weakness
  • hives or welts, itching, or skin rash
  • hives, itching, puffiness, or swelling of the eyelids or around the eyes, face, lips, or tongue
  • increased thirst
  • joint or muscle pain
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • light-colored stools
  • loss of consciousness
  • red skin lesions, often with a purple center
  • red, irritated eyes
  • redness of the skin
  • sores, ulcers, or white spots in the mouth or on the lips
  • swelling of the face, ankles, or hands
  • tearing
  • tightness in the chest
  • unpleasant breath odor
  • upper right stomach pain
  • vomiting of blood
  • yellow eyes and skin
Type Small Molecule
Accession Number DB00476  (APRD00060)
Groups Approved
Synonyms
  • (3S)-N-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propan-1-amine
  • (S)-duloxetine
UNII O5TNM5N07U
CAS number 116539-59-4
Weight Average: 297.415
Monoisotopic: 297.118734925
Chemical Formula C18H19NOS
InChI
InChI=1S/C18H19NOS/c1-19-12-11-17(18-10-5-13-21-18)20-16-9-4-7-14-6-2-3-8-15(14)16/h2-10,13,17,19H,11-12H2,1H3/t17-/m0/s1
IUPAC Name
methyl[(3S)-3-(naphthalen-1-yloxy)-3-(thiophen-2-yl)propyl]amine
Protein binding

Protein binding is greater than 90%.

Toxicity

Oral, rat LD50: 491 mg/kg for males and 279 mg/kg for females. Symptoms of overdose include tremors, convulsions, reduced activity, slow pupillary response, intermittent tremors, and rigidity.

Half life

12 hours (range 8-17 hours)

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