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Uphadol Extra (Brand name: Cafergot) Online

  • €0,55
  • Brand name: Cafergot
  • Verfügbarkeit: Lagernd
  • Wirkstoff: caffeine
Uphadol Extra wird zur Behandlung von Anfällen Migräneartiger Kopfschmerzen (z.B. Migräne mit und ohne Aura, Kopfschmerzen durch Einwirkung von Histaminstoffen) verwendet.
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Alle anzeigen

100 mg
Produktname Pro Pille Pro Packung  
30 pillen €0,94 €28,05
60 pillen €0,73 €56,10 €43,55
90 pillen €0,66 €84,15 €59,05
120 pillen €0,62 €112,20 €74,56
180 pillen €0,59 €168,30 €105,57
270 pillen €0,56 €252,46 €152,07
360 pillen €0,55 €336,61 €198,61

Drug Name

Uphadol Extra (Caffeine/Ergotamine) 

Drug Uses

Uphadol Extra is used for preventing and treating certain kinds of headaches (e.g., migraines, migraine variants, histaminic cephalalgia). It may also be used for other conditions as determined by your doctor. 

How to use

Use Uphadol Extra as directed by your doctor. 
Uphadol Extra may be taken with or without food.
Eating grapefruit or drinking grapefruit juice may affect the amount of Uphadol Extra in your blood. Talk with your doctor before including grapefruit or grapefruit juice in your diet.
Uphadol Extra is only to be used as needed for a migraine attack.
Take Uphadol Extra at the first sign of a headache. If the initial dose does not relieve your headache, additional doses may be needed according to your doctor's instructions. Do not take a dose of Uphadol Extra within 30 minutes of your last dose.
Do not take more than 6 tablets for a single migraine headache or more than 10 tablets during any 7-day period without first checking with your doctor.
Ask your health care provider any questions you may have about how to use Uphadol Extra.

Drug Class and Mechanism

Uphadol Extra is a combination of 2 vasoconstrictors. It works by constricting blood vessels in the lining of the brain, which helps to decrease the pain from migraine headaches. 

Missed Dose

If you miss a dose of Uphadol Extra and you still have a headache, take it as soon as you remember. Do not take a dose of Uphadol Extra within 30 minutes of your last dose. Do not take 2 doses at once. 
Storage

Store Uphadol Extra at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Keep Uphadol Extra out of the reach of children and away from pets.

Warnings/Precautions

Do not use Uphadol Extra if: 
you are allergic to any ingredient in Uphadol Extra.
you are pregnant or may become pregnant.
you have blood vessel problems (e.g., peripheral vascular disease), coronary heart disease, high blood pressure, liver or kidney problems, or severe infection (e.g., sepsis).
you are taking an azole antifungal (e.g., itraconazole, ketoconazole, voriconazole), delavirdine, HIV protease inhibitors (e.g., delavirdine, indinavir, nelfinavir, ritonavir), efavirenz, a ketolide antibiotic (e.g., telithromycin), a macrolide antibiotic (e.g., clarithromycin, erythromycin), or selective 5-HT agonists (e.g., sumatriptan, eletriptan).
Contact your doctor or health care provider right away if any of these apply to you.

Important: 

Do not exceed the recommended dose or take Uphadol Extra for longer than prescribed without checking with your doctor. Uphadol Extra is not for long-term daily use.
Do not take Uphadol Extra for any other kind of headaches. Uphadol Extra is not effective in treating other types of headaches.
Use of nicotine may increase the risk of severe side effects with Uphadol Extra . Talk to you doctor before using Uphadol Extra if you smoke or use any other kind of nicotine.
Use Uphadol Extra with extreme caution in children. Safety and effectiveness have not been confirmed.
Pregnancy and breast-feeding: Do not use Uphadol Extra if you are pregnant. If you suspect that you could be pregnant, contact your doctor immediately. Uphadol Extra should not be taken during labor and delivery. Uphadol Extra is excreted in breast milk. If you are or will be breast-feeding while you are using Uphadol Extra , check with your doctor or pharmacist to discuss the risks to your baby.

Possible Side Effects

Check with your doctor if any of these most common side effects persist or become bothersome: 
nausea.
Seek medical attention right away if any of these severe side effects occur:

severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blue color of the fingers or toes; chest pain or tightness; cold or pale fingers or toes; diarrhea; dizziness; hallucinations; headache; irregular heartbeat; leg cramps or weakness; mental or mood changes; muscle pain; numbness or tingling of the hands, feet, or skin; ringing in the ears; seizure; severe or persistent nausea or vomiting; shortness of breath; swelling; temporary fast or slow heartbeat; vomiting; weak pulse.

More Information

Uphadol Extra is to be used only by the patient for whom it is prescribed. Do not share it with other people. 
If your symptoms do not improve or if they become worse, check with your doctor.

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    Weniger Gut           Gut
Type Small Molecule
Accession Number DB00696  (APRD00677)
Groups Approved
Synonyms
  • (5'α)-12'-hydroxy-2'-methyl-5'-(phenylmethyl)ergotoman-3',6',18-trione
  • 12'-Hydroxy-2'-methyl-5'alpha-(phenylmethyl)ergotaman-3',6',18-trione
  • 12'-hydroxy-2'-methyl-5'α-(phenylmethyl)ergotaman-3',6',18-trione
  • Ergotamin
  • Ergotamina
  • Ergotamine
  • Ergotaminum
UNII PR834Q503T
CAS number 113-15-5
Weight Average: 581.6615
Monoisotopic: 581.263819255
Chemical Formula C33H35N5O5
InChI
InChI=1S/C33H35N5O5/c1-32(35-29(39)21-15-23-22-10-6-11-24-28(22)20(17-34-24)16-25(23)36(2)18-21)31(41)38-26(14-19-8-4-3-5-9-19)30(40)37-13-7-12-27(37)33(38,42)43-32/h3-6,8-11,15,17,21,25-27,34,42H,7,12-14,16,18H2,1-2H3,(H,35,39)/t21-,25-,26+,27+,32-,33+/m1/s1
IUPAC Name
(4R,7R)-N-[(1S,2S,4R,7S)-7-benzyl-2-hydroxy-4-methyl-5,8-dioxo-3-oxa-6,9-diazatricyclo[7.3.0.0^{2,6}]dodecan-4-yl]-6-methyl-6,11-diazatetracyclo[7.6.1.0^{2,7}.0^{12,16}]hexadeca-1(16),2,9,12,14-pentaene-4-carboxamide
Protein binding Not Available
Toxicity

Signs of overexposure include irritation, nausea, vomiting, headache, diarrhea, thirst, coldness of skin, pruritus, weak pulse, numbness, tingling of extremities, and confusion.

Half life

2 hours

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